Fantastic news -- Mono 2.6 and MonoDevelop 2.2 are out! Be sure to read the detailed Mono 2.6 release notes.
If you are running openSUSE 11.2, it's quite simple to safely update your entire Mono stack and stay up to date with any 2.6 updates:
zypper ar -f -n Mono http://ftp.novell.com/pub/mono/download-stable/openSUSE_11.2 repo-monozypper mr -p 10 repo-monozypper refreshzypper dup -r repo-mono
Those instructions will change the Mono distribution from openSUSE to the upstream Mono repositories.
I highly recommend installing MonoDevelop 2.2 (zypper in monodevelop), though if you already had it installed, the above will update you to the 2.2 release.
Integrated Mono 2.6 soft debugger in MonoDevelop 2.2
A huge congratulations and thank you to the Mono team for another exceptional major Mono milestone!
UPDATE: apparently there is a problem on the x86_64 build in the openSUSE Build Service. This appears to be an OBS bug, but for this reason, it's recommended that you use the repositories at http://ftp.novell.com/pub/mono/download-stable.